资源类型

期刊论文 924

年份

2024 1

2023 85

2022 85

2021 89

2020 74

2019 57

2018 72

2017 41

2016 38

2015 60

2014 38

2013 36

2012 31

2011 42

2010 35

2009 29

2008 18

2007 12

2006 9

2005 9

展开 ︾

关键词

可再生能源 11

可持续发展 10

节能 10

能源 9

核能 7

能源安全 6

2035 4

新能源 4

氢能 4

碳中和 4

能源战略 4

能源结构 4

能源转型 4

能源革命 4

节能减排 4

节能环保 4

中长期 3

关键技术 3

太阳能 3

展开 ︾

检索范围：

排序： 展示方式：

Mechanism of insulin resistance in obesity: a role of ATP

《医学前沿（英文）》 2021年 第15卷 第3期   页码 372-382 doi: 10.1007/s11684-021-0862-5

摘要： Obesity increases the risk of type 2 diabetes through the induction of insulin resistance. The mechanism of insulin resistance has been extensively investigated for more than 60 years, but the essential pathogenic signal remains missing. Existing hypotheses include inflammation, mitochondrial dysfunction, hyperinsulinemia, hyperglucagonemia, glucotoxicity, and lipotoxicity. Drug discoveries based on these hypotheses are unsuccessful in the development of new medicines. In this review, multidisciplinary literature is integrated to evaluate ATP as a primary signal for insulin resistance. The ATP production is elevated in insulin-sensitive cells under obese conditions independent of energy demand, which we have named “mitochondrial overheating.” Overheating occurs because of substrate oversupply to mitochondria, leading to extra ATP production. The ATP overproduction contributes to the systemic insulin resistance through several mechanisms, such as inhibition of AMPK, induction of mTOR, hyperinsulinemia, hyperglucagonemia, and mitochondrial dysfunction. Insulin resistance represents a feedback regulation of energy oversupply in cells to control mitochondrial overloading by substrates. Insulin resistance cuts down the substrate uptake to attenuate mitochondrial overloading. The downregulation of the mitochondrial overloading by medicines, bypass surgeries, calorie restriction, and physical exercise leads to insulin sensitization in patients. Therefore, ATP may represent the primary signal of insulin resistance in the cellular protective response to the substrate oversupply. The prevention of ATP overproduction represents a key strategy for insulin sensitization.

关键词： type 2 diabetes     energy expenditure     mitochondria     hyperinsulinemia     hyperglucagonemia     AMPK    

HTML PDF 收藏

PM concentration declining saves health expenditure in China

《环境科学与工程前沿（英文）》 2023年 第17卷 第7期 doi: 10.1007/s11783-023-1690-4

摘要：

● Monthly hospitalization expenses are sensitive to increases in PM2.5 exposure.

关键词： Air pollution     Health expenditure     PM2.5 concentration     Economic impact     Heterogeneous effect    

HTML PDF 收藏

Mechanisms of insulin resistance in obesity

null

《医学前沿（英文）》 2013年 第7卷 第1期   页码 14-24 doi: 10.1007/s11684-013-0262-6

摘要：

Obesity increases the risk for type 2 diabetes through induction of insulin resistance. Treatment of type 2 diabetes has been limited by little translational knowledge of insulin resistance although there have been several well-documented hypotheses for insulin resistance. In those hypotheses, inflammation, mitochondrial dysfunction, hyperinsulinemia and lipotoxicity have been the major concepts and have received a lot of attention. Oxidative stress, endoplasmic reticulum (ER) stress, genetic background, aging, fatty liver, hypoxia and lipodystrophy are active subjects in the study of these concepts. However, none of those concepts or views has led to an effective therapy for type 2 diabetes. The reason is that, there has been no consensus for a unifying mechanism of insulin resistance. In this review article, literature is critically analyzed and reinterpreted for a new energy-based concept of insulin resistance, in which insulin resistance is a result of energy surplus in cells. The energy surplus signal is mediated by ATP and sensed by adenosine monophosphate-activated protein kinase (AMPK) signaling pathway. Decreasing ATP level by suppression of production or stimulation of utilization is a promising approach in the treatment of insulin resistance. In support, many of existing insulin sensitizing medicines inhibit ATP production in mitochondria. The effective therapies such as weight loss, exercise, and caloric restriction all reduce ATP in insulin sensitive cells. This new concept provides a unifying cellular and molecular mechanism of insulin resistance in obesity, which may apply to insulin resistance in aging and lipodystrophy.

关键词： type 2 diabetes     energy expenditure     inflammation     lipotoxicity     mitochondria     hyperinsulinemia     adenosine monophosphate-activated protein kinase (AMPK)    

HTML PDF 收藏

Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes

null

《医学前沿（英文）》 2015年 第9卷 第2期   页码 139-145 doi: 10.1007/s11684-015-0377-z

摘要：

In obesity, chronic inflammation is believed to induce insulin resistance and impairs adipose tissue function. Although this view is supported by a large body of literature, it has been challenged by growing evidence that pro-inflammatory cytokines may favor insulin sensitivity through induction of energy expenditure. In this review article, interleukin 15 (IL-15) is used as a new example to explain the beneficial effects of the pro-inflammatory cytokines. IL-15 is secreted by multiple types of cells including macrophages, neutrophils and skeletal muscle cells. IL-15 expression is induced in immune cells by endotoxin and in muscle cells by physical exercise. Its transcription is induced by transcription factor NF-κB. IL-15 binds to its receptor that contains three different subunits (α, β and γ) to activate JAK/STAT, PI3K/Akt, IKK/NF-κB and JNK/AP1 pathways in cells. In the regulation of metabolism, IL-15 reduces weight gain without inhibiting food intake in rodents. IL-15 suppresses lipogenesis, stimulates brown fat function, improves insulin sensitivity through weight loss and energy expenditure. In human, circulating IL-15 is negatively associated with body weight. In the immune system, IL-15 stimulates proliferation and differentiation of T cells, NK cells, monocytes and neutrophils. In the anti-obesity effects of IL-15, T cells and NK cells are not required, but leptin receptor is required. In summary, evidence from human and rodents supports that the pro-inflammatory cytokine IL-15 may enhance energy expenditure to protect the body from obesity and type 2 diabetes. The mechanism of IL-15 action remains to be fully uncovered in the regulation of energy expenditure.

关键词： inflammation     obesity     cytokine     energy expenditure     insulin resistance    

HTML PDF 收藏

Ablation of steroid receptor coactivator-3 in mice impairs adipogenesis and enhances energy expenditure

Ling-Yan XU PhD, Xin-Ran MA PhD, Xiao-Ying LI PhD, MD, Shu WANG PhD, Guang NING PhD, MD, Jie-Li LI PhD, Jian-Ming XU PhD,

《医学前沿（英文）》 2010年 第4卷 第2期   页码 229-234 doi: 10.1007/s11684-010-0028-3

摘要： Obesity is a medical condition in which excess body fat has accumulated to an extent and may have an adverse effect on health, leading to reduced life expectancy, impaired energy homeostasis and increased health problems. The p160 steroid receptor coactivator (SRC) gene family members have been suggested to be involved in energy homeostasis, but the impact of SRC-3 ablation on white and brown adipose tissue needs to be elucidated. In the current study, we collected data and carried out morphological studies on the effect of SRC-3 deficiency on white adipose tissue (WAT) and brown adipose tissue (BAT). Primary cells were cultured to investigate the differentiation ability of both adipocytes. Western blot was applied to detect the expression of master genes governing adipogenesis and thermogenesis. We observed that SRC-3 mice were lean, with reduced WAT and decreased serum leptin levels, mainly due to the smaller white adipocyte size caused by impaired adipogenesis, presented by decreased peroxisome proliferator activated receptor (PPAR) expression. In the BAT, the lipid droplets decreased significantly in SRC-3 mice as demonstrated by histological analysis and electron microscopic observation, which could be explained by enhanced thermogenesis. The expression of thermogenic marker gene PPAR coactivator 1α and uncoupling protein-1 increased in BAT of SRC-3 mice, which proved our observations. Collectively, these results demonstrate that SRC-3 plays a key role in adipogenesis and energy expenditure.

关键词： steroid receptor coactivator-3     white adipose tissue     brown adipose tissue     obesity     adipocytes     energy expenditure    

HTML PDF 收藏

Effect of the new maternity insurance scheme on medical expenditures for caesarean delivery in Wuxi, China: a retrospective pre/post-reform case study

null

《医学前沿（英文）》 2016年 第10卷 第4期   页码 473-480 doi: 10.1007/s11684-016-0479-

摘要：

Aiming to control rising medical expenditures and help improve China’s healthcare systems, this study examined whether a cap-based medical insurance scheme with shared financial interest between the insurance and healthcare providers is effective in containing hospitals’ C-section medical expenditures. We used 6547 caesarean delivery case records from a teaching tertiary-level general public hospital located in Wuxi, China (2004–2013), and used the Chow test to investigate the possibility of significant variation in mean medical expenditures for caesarean deliveries pre- and post-reform. We also used paired sample t-tests and linear regression models to compare the mean medical expenditures between insured and uninsured women undergoing caesarean delivery during the post-reform period. After the scheme’s implementation, medical expenditures for caesarean deliveries declined and the medical expenditures of women covered by the scheme were significantly lower than those of uninsured patients. These findings indicated the scheme’s effectiveness in minimizing caesarean delivery expenditures. The cap-based medical insurance scheme with shared financial interest between insurance and healthcare providers would likely steer healthcare providers’ behaviors in a more cost-effective direction.

关键词： maternity insurance scheme     financial incentive     caesarean delivery     medical expenditure     China    

HTML 收藏

Microwave-induced high-energy sites and targeted energy transition promising for efficient energy deployment

《能源前沿（英文）》 2022年 第16卷 第6期   页码 931-942 doi: 10.1007/s11708-021-0771-y

摘要： Diverse interactions between microwaves and irradiated media provide a solid foundation for identifying novel organization pathways for energy flow. In this study, a high-energy-site phenomenon and targeted-energy transition mechanism were identified in a particular microwave heating (MH) process. Intense discharges were observed when microwaves were imposed on irregularly sized SiC particles, producing tremendous heat that was 8-fold the amount generated in the discharge-free case. Energy efficiency was thereby greatly improved in the electricity-microwaves-effective heat transition. Meanwhile, the dispersed microwave field energy concentrated in small sites, where local temperatures could reach 2000°C– 4000°C, with the energy density reaching up to 4.0 × 105 W/kg. This can be called a high-energy site phenomenon which could induce further processes or reactions enhancement by coupling effects of heat, light, and plasma. The whole process, including microwave energy concentration and intense site-energy release, shapes a targeted-energy transition mechanism that can be optimized in a controlled manner through morphology design. In particular, the discharge intensity, frequency, and high-energy sites were strengthened through the fabrication of sharp nano/microstructures, conferring twice the energy efficiency of untreated metal wires. The microwave-induced high-energy sites and targeted energy transition provide an important pathway for high-efficiency energy deployment and may lead to promising applications.

关键词： microwave discharge     high-energy sites     targeted-energy transition     morphology design     energy efficiency    

HTML PDF 收藏

Analysis of energy saving optimization of campus buildings based on energy simulation

Dingding TONG, Jing ZHAO

《能源前沿（英文）》 2013年 第7卷 第3期   页码 388-398 doi: 10.1007/s11708-013-0273-7

摘要： The energy consumption of campus buildings has specific characteristics, because of the concentrated distribution of people’s working time and locations that change in line with distinct seasonal features. The traditional energy system design and operation for campus buildings is only based on the constant room temperature, such as 25°C in summer and 18°C in winter in China, not taking into consideration the real heating or cooling load characteristics of campus buildings with different functions during the whole day and whole year, which usually results in a lot of energy waste. This paper proposes to set different set-point temperatures in different operation stages of public and residential campus buildings to reduce the heating and cooling design load for energy station and total campus energy consumption for annual operation. Taking a campus under construction in Tianjin, China as an example, two kinds of single building models were established as the typical public building and residential building models on the campus. Besides, the models were simulated at both set-point room temperature and constant room temperature respectively. The comparison of the simulation results showed that the single building energy saving method of the peak load clipping could be used for further analysis of the annual energy consumption of campus building groups. The results proved that the strategy of set-point temperature optimization could efficiently reduce the design load and energy consumption of campus building groups.

关键词： campus buildings     set-point temperature     energy simulation     energy saving optimization    

HTML PDF 收藏

Modeling China’s energy dilemma: conflicts among energy saving, energy security, and CO 2 mitigation

Feng FU, Zheng LI, Linwei MA,

《能源前沿（英文）》 2010年 第4卷 第3期   页码 295-300 doi: 10.1007/s11708-010-0104-z

摘要： This study analyzes China’s future energy scenarios stretching until 2050 under different policy portfolios of energy security (e.g., oil import dependency) and CO emissions control. Four scenarios, namely, ① business as usual, ② strong oil import dependency (OID) control, ③ strong CO emissions control, and ④ twofold emphasis on OID and CO emissions control, are designed. The results reveal the existence of conflicts among China’s multiple objectives, particularly energy saving, energy security, and CO mitigation. Based on the analysis, an improvement in China’s efficiency in fossil energy conversion and the promotion of the utilization of non-fossil energy such as nuclear, wind, and hydro energy are recommended. The over-development of coal-derived fuels should also be avoided because of incremental coal consumption and CO emissions. Furthermore, research on and development of carbon capture and storage technologies should be promoted, while the energy efficiency loss caused by integrating these technologies into energy systems should be reduced in view of the high possibility of stricter standards for CO emissions in the future.

关键词： Energy dilemma     energy saving     energy security     CO2 mitigation    

HTML PDF 收藏

Blockchain in energy systems: values, opportunities, and limitations

《能源前沿（英文）》 2022年 第16卷 第1期   页码 9-18 doi: 10.1007/s11708-022-0818-8

摘要： The structure of a power energy system is becoming more distributed than before. It becomes challenging to manage such a system in a centralized way, because a central authority may not exist or may not be trusted by all parties. Blockchain is a promising tool to address this challenge, by enabling trusted collaboration in the absence of a trusted central authority. Its use in the energy sector has been pioneered by several pilot projects. However, to date the energy sector has not seen large-scale deployment of blockchain, partly because the founders of those pilot projects, the public, and utilities have not reached consensus on the values and limitations of blockchain in energy. This perspective aims to bridge this gap. First, the philosophy and unique values of blockchain are discussed. Second, some promising blockchain-based applications in energy systems are presented. Third, some common misunderstandings of blockchain in energy are discussed. Last, some frequently-asked questions from utilities are discussed. Hopefully this perspective can help advance large-scale deployment of blockchain in energy systems.

关键词： blockchain     immutability     energy trading     energy management     data synchronization    

HTML PDF 收藏

Unconventional energy: Seeking the ways to innovate energy science and technology

Jing LIU, Zhixiong GUO

《能源前沿（英文）》 2018年 第12卷 第2期   页码 195-197 doi: 10.1007/s11708-018-0568-9

HTML PDF 收藏

Impact of household transitions on domestic energy consumption and its applicability to urban energy

Benachir MEDJDOUB, Moulay Larbi CHALAL

《工程管理前沿（英文）》 2017年 第4卷 第2期   页码 171-183 doi: 10.15302/J-FEM-2017029

摘要： The household sector consumes roughly 30% of Earth’s energy resources and emits approximately 17% of its carbon dioxide. As such, developing appropriate policies to reduce the CO emissions, which are associated with the world’s rapidly growing urban population, is a high priority. This, in turn, will enable the creation of cities that respect the natural environment and the well-being of future generations. However, most of the existing expertise focuses on enhancing the thermal quality of buildings through building physics while few studies address the social and behavioral aspects. In fact, focusing on these aspects should be more prominent, as they cause between 4% and 30% of variation in domestic energy consumption. Premised on that, the aim of this study was to investigate the effect in the context of the UK of household transitions on household energy consumption patterns. To achieve this, we applied statistical procedures (e.g., logistic regression) to official panel survey data comprising more than 5500 households in the UK tracked annually over the course of 18 years. This helped in predicting future transition patterns for different household types for the next 10 to 15 years. Furthermore, it enabled us to study the relationship between the predicted patterns and the household energy usage for both gas and electricity. The findings indicate that the life cycle transitions of a household significantly influence its domestic energy usage. However, this effect is mostly positive in direction and weak in magnitude. Finally, we present our developed urban energy model “EvoEnergy” to demonstrate the importance of incorporating such a concept in energy forecasting for effective sustainable energy decision-making.

关键词： urban energy planning     household transitions     smart cities     energy forecasting     household projection     serious gaming    

HTML PDF 收藏

Linking renewables and fossil fuels with carbon capture via energy storage for a sustainable energy future

Dawid P. Hanak, Vasilije Manovic

《化学科学与工程前沿（英文）》 2020年 第14卷 第3期   页码 453-459 doi: 10.1007/s11705-019-1892-2

摘要： Renewable energy sources and low-carbon power generation systems with carbon capture and storage (CCS) are expected to be key contributors towards the decarbonisation of the energy sector and to ensure sustainable energy supply in the future. However, the variable nature of wind and solar power generation systems may affect the operation of the electricity system grid. Deployment of energy storage is expected to increase grid stability and renewable energy utilisation. The power sector of the future, therefore, needs to seek a synergy between renewable energy sources and low-carbon fossil fuel power generation. This can be achieved via wide deployment of CCS linked with energy storage. Interestingly, recent progress in both the CCS and energy storage fields reveals that technologies such as calcium looping are technically viable and promising options in both cases. Novel integrated systems can be achieved by integrating these applications into CCS with inherent energy storage capacity, as well as linking other CCS technologies with renewable energy sources via energy storage technologies, which will maximise the profit from electricity production, mitigate efficiency and economic penalties related to CCS, and improve renewable energy utilisation.

关键词： carbon capture     energy storage     renewable energy sources     decarbonisation     fossil fuels    

HTML PDF 收藏

Levelized costs of the energy chains of new energy vehicles targeted at carbon neutrality in China

《工程管理前沿（英文）》   页码 392-408 doi: 10.1007/s42524-022-0212-6

摘要： The diffusion of new energy vehicles (NEVs), such as battery electric vehicles (BEVs) and fuel cell vehicles (FCVs), is critical to the transportation sector’s deep decarbonization. The cost of energy chains is an important factor in the diffusion of NEVs. Although researchers have addressed the technological learning effect of NEVs and the life cycle emissions associated with the diffusion of NEVs, little work has been conducted to analyze the life cycle costs of different energy chains associated with different NEVs in consideration of technological learning potential. Thus, relevant information on investment remains insufficient to promote the deployment of NEVs. This study proposes a systematic framework that includes various (competing or coordinated) energy chains of NEVs formed with different technologies of power generation and transmission, hydrogen production and transportation, power-to-liquid fuel, and fuel transportation. The levelized costs of three typical carbon-neutral energy chains are investigated using the life cycle cost model and considering the technological learning effect. Results show that the current well-to-pump levelized costs of the energy chains in China for BEVs, FCVs, and internal combustion engine vehicles (ICEVs) are approximately 3.60, 4.31, and 2.21 yuan/GJ, respectively, and the well-to-wheel levelized costs are 4.50, 6.15, and 7.51 yuan/GJ, respectively. These costs primarily include raw material costs, and they vary greatly for BEVs and FCVs from resource and consumer costs. In consideration of the technological learning effect, the energy chains’ well-to-wheel levelized costs are expected to decrease by 24.82% for BEVs, 27.12% for FCVs, and 19.25% for ICEVs by 2060. This work also summarizes policy recommendations on developing energy chains to promote the diffusion of NEVs in China.

关键词： energy chain     new energy vehicle     internal combustion engine vehicle     life cycle cost     technological learning    

HTML PDF 收藏

Energy neutrality potential of wastewater treatment plants: A novel evaluation framework integratingenergy efficiency and recovery

《环境科学与工程前沿（英文）》 2022年 第16卷 第9期 doi: 10.1007/s11783-022-1549-0

摘要：

• Framework of indicators was established based on energy efficiency and recovery.

关键词： Wastewater treatment plants     Energy neutrality potential     Energy efficiency     Energy recovery     Evaluation framework    

HTML PDF 收藏

标题 作者 时间 类型 操作

Mechanism of insulin resistance in obesity: a role of ATP

期刊论文

PM concentration declining saves health expenditure in China

期刊论文

Mechanisms of insulin resistance in obesity

null

期刊论文

Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes

null

期刊论文

Ablation of steroid receptor coactivator-3 in mice impairs adipogenesis and enhances energy expenditure

Ling-Yan XU PhD, Xin-Ran MA PhD, Xiao-Ying LI PhD, MD, Shu WANG PhD, Guang NING PhD, MD, Jie-Li LI PhD, Jian-Ming XU PhD,

期刊论文

Effect of the new maternity insurance scheme on medical expenditures for caesarean delivery in Wuxi, China: a retrospective pre/post-reform case study

null

期刊论文

Microwave-induced high-energy sites and targeted energy transition promising for efficient energy deployment

期刊论文

Analysis of energy saving optimization of campus buildings based on energy simulation

Dingding TONG, Jing ZHAO

期刊论文

Modeling China’s energy dilemma: conflicts among energy saving, energy security, and CO 2 mitigation

Feng FU, Zheng LI, Linwei MA,

期刊论文

Blockchain in energy systems: values, opportunities, and limitations

期刊论文

Unconventional energy: Seeking the ways to innovate energy science and technology

Jing LIU, Zhixiong GUO

期刊论文

Impact of household transitions on domestic energy consumption and its applicability to urban energy

Benachir MEDJDOUB, Moulay Larbi CHALAL

期刊论文

Linking renewables and fossil fuels with carbon capture via energy storage for a sustainable energy future

Dawid P. Hanak, Vasilije Manovic

期刊论文

Levelized costs of the energy chains of new energy vehicles targeted at carbon neutrality in China

期刊论文

Energy neutrality potential of wastewater treatment plants: A novel evaluation framework integratingenergy efficiency and recovery

期刊论文